And patients taking Niaspan (generic: niacin) or Advicor (generic: niacin extended-release and lovastatin) could also experience uncomfortable itching and flushing. It also increases your risk of experiencing these medications’ side effects including restlessness, loss of appetite, depression, and impaired motor control. Chronic alcohol abuse can elevate the risk for liver disease, such as cirrhosis. Those side effects may not seem so serious when you’re aiming to head to dreamland anyway. Including brand-name drugs like: Reglan, Zantac, Tagamet, Maalox, Rolaids, Nexium, Prilosec. Even antihistamines that are advertised as non-drowsy (such as Claritin and Allegra) can have this effect in some people, says Rech, especially when paired with alcohol. Disulfiram In 1951, this was the first drug that the FDA approved for alcohol use disorder. Bottom line: Don’t drink if you’re taking one of the antibiotics listed above, or for 72 hours after your last dose, says Rech. Not sure what class of drug you’re taking? Prescription drugs all come with side effects, or the risk of side effects. The Top 15 Most Dangerous Drugs. One of the side effects of valproic acid is sleepiness, and alcohol can increase that effect, the NIH says. "Mixing alcohol with Tylenol/acetaminophen can cause severe liver damage and even failure. There are certain types of over-the-counter drugs that do not mix with alcohol. Both classes of drugs share some additional risks when combined with alcohol. This group of addictive drugs includes heroin, morphine, methadone, oxycodone, hydrocodone, and codeine.Narcotic prescription painkillers are dangerous enough on their own, but mixing these drugs with alcohol increases their relaxing, … If that’s the case for you, be sure to avoid alcohol. Alcohol often has harmful interactions with prescription medications, over-the-counter drugs, and even some herbal remedies. Do not use isopropyl alcohol on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. It also can put you at risk for internal bleeding, heart problems, and difficulties in breathing. "Mixing alcohol with common over the counter anti-inflammatory pain medications like ibuprofen and Naprosyn can cause GI upset, ulcers, and even stomach bleeding," says Dr. Arthur. There’s a similar warning for an other type of angina medication called isosorbide. And that’s not a good thing: Even one drink can cause drowsiness, dizziness, and slowed breathing when taken with another sedative. Alcohol withdrawal is common, but delirium tremens only occurs in 5% of people who have alcohol withdrawal. Including brand-name drugs like: Coumadin, Eliquis, Bevyxxa, Pradaxa. Doing so can result in abnormally low blood sugar levels, nausea, vomiting, headaches, a rapid heartbeat, or a sudden change in blood pressure, according to the NIAAA. Bottom line: Talk to your doctor about what risks drinking could pose based on the specific drugs you’re taking. Depending on the magnitude of physical dependence, additional symptoms may continue to arise beyond 24 hours, with some potentially severe effects emerging 2 to 4 days after abstinence. A Top Neurosurgeon’s Best Tips for Brain Health, Meghan McCain Shares First Photo of Her Daughter, Buddy Valastro Made a Huge Cake for Hospital Staff. One type of antidepressant—monoamine oxidase inhibitors (MAOIs)—can cause heart problems and dangerously high blood pressure when combined with booze. Over-the-counter allergy remedies like Benadryl and Zyrtec contain antihistamines, a class of drug that can cause excessive drowsiness and may put you at risk if you’re driving a car or operating machinery—even more so when you’ve also had a drink or two. 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